Patient support and financial assistance

Supporting you and your patients every step of the way

*Subject to terms and conditions.

Gamunex Connexions

Gamunex Connexions offers financial help for your patients and administrative help for your office.

  • Help your patients get access to GAMUNEX-C with copay and patient assistance programs
  • Get help and guidance on coverage authorization and reimbursement through office support

Offering maximum support for your PIDD patients with a 20% subcutaneous IG option

XEMBIFY® is a 20% immune globulin indicated for treatment of primary humoral immunodeficiency disease (PIDD) in patients 2 years of age and older. XEMBIFY is for subcutaneous administration only.

For all your questions regarding financial assistance, coverage, and reimbursement, call Gamunex Connexions at 1-888-MYGAMUNEX (1-888-694-2686)

Financial support

Supporting your patients with financial assistance

Patients can receive up to $10,000 of copay support per calendar year on their prescription for GAMUNEX-C*

  • Copay Assistance Program covers deductibles, copayment, and coinsurance medication costs
  • Patients may be eligible for IV administration in CIDP and both IV and Sub Q administration in PIDD
  • Eligibility—patients must be enrolled in Gamunex Connexions and have commercial insurance that:
    • Covers medication costs for GAMUNEX-C
    • Allows for copay or coupon assistance

Patient Assistance Program

  • Provides uninsured CIDP patients access to the therapy they need

Committed case managers

  • A dedicated, single point of contact for you, your office staff, and your patients

Billing assistance


  1. REGISTER your patient at the medical billing portal
  2. OPT IN your patient to qualify for financial assistance
  3. PROCESS a claim with instant adjudication through the medical billing portal


SUBMIT a claim to the primary payer first. If your patient requires copay assistance, submit the balance to Medmonk as a secondary payer coordination of benefits (COB) using the following:

BIN: 016664



Encourage your patients to learn more about Gamunex Connexions by calling 1-888-MYGAMUNEX (1-888-694-2686) or visiting the website

Forms for your PIDD patients

Download these helpful forms to share with your patients.


*This manufacturer coupon program is not valid for prescriptions reimbursed, in whole or in part, by Medicaid, Medicare, Medigap, VA, DoD, TRICARE, or any other federal or state healthcare programs, including state pharmaceutical assistance programs, and where prohibited by the health insurance provider or by law. This coupon program provides a maximum benefit of $10,000 for eligible out-of-pocket costs available over a calendar year period. Eligible costs include deductible, copayment, and coinsurance costs for GAMUNEX-C medication. Nonmedication expenses, such as ancillary supplies or administration-related costs, are not eligible. To be eligible, patients must 1) be starting or receiving treatment with (and have a current prescription for) GAMUNEX-C with an ICD9 or ICD10, as applicable of a chronic inflammatory demyelinating polyneuropathy (CIDP) or primary immunodeficiency disease (PIDD); and 2) have commercial insurance that covers medication costs for GAMUNEX-C treatment and allows for copay/coupon assistance. Acceptance of this offer must be consistent with the terms of benefits provided by patient's health insurance provider. Offer limited to outpatient IG treatment and may not be combined with any other coupon, discount, prescription savings card, rebate, free trial, or other offer. This program is only valid for residents of the United States, excluding Puerto Rico and other US territories. Grifols reserves the right to change or discontinue this program at any time without notice. This is not health insurance.

XEMBIFY® (immune globulin subcutaneous, human–klhw), 20% and GAMUNEX®-C (immune globulin injection [human], 10% caprylate/chromatography purified) are immune globulins indicated for treatment of primary humoral immunodeficiency disease (PIDD) in patients 2 years of age and older.

XEMBIFY is a 20% solution for subcutaneous administration only. GAMUNEX-C is a 10% solution for intravenous and subcutaneous administration in PIDD.

Important Safety Information


Thrombosis may occur with immune globulin products, including XEMBIFY and GAMUNEX-C. Risk factors may include: advanced age, prolonged immobilization, hypercoagulable conditions, history of venous or arterial thrombosis, estrogens, indwelling vascular catheters, hyperviscosity, and cardiovascular risk factors. Thrombosis may occur in the absence of known risk factors.

For patients at risk of thrombosis, administer XEMBIFY and GAMUNEX-C at the minimum dose and infusion rate practicable. Ensure adequate hydration in patients before administration. Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk of hyperviscosity.


Renal dysfunction, acute renal failure, osmotic nephrosis, and death may occur with GAMUNEX-C in predisposed patients. Patients predisposed to renal dysfunction include those with any degree of preexisting renal insufficiency, diabetes mellitus, age greater than 65, volume depletion, sepsis, paraproteinemia, or patients receiving known nephrotoxic drugs.

Renal dysfunction and acute renal failure occur more commonly in patients receiving IVIG products containing sucrose. GAMUNEX-C does not contain sucrose.

For patients at risk of renal dysfunction or failure, administer GAMUNEX-C at the minimum concentration available and the minimum infusion rate practicable.

XEMBIFY and GAMUNEX-C are contraindicated in:

Patients who have had an anaphylactic or severe systemic reaction to the administration of human immune globulin.

IgA-deficient patients with antibodies against IgA and a history of hypersensitivity.

Warnings and Precautions
Hypersensitivity. Severe hypersensitivity reactions may occur with immune globulin products, including XEMBIFY and GAMUNEX-C. In case of hypersensitivity, discontinue infusion immediately and institute appropriate treatment. XEMBIFY and GAMUNEX-C contain IgA. Patients with known antibodies to IgA may have a greater risk of developing potentially severe hypersensitivity and anaphylactic reactions.

Thrombosis. Thrombosis may occur following treatment with immune globulin products, including XEMBIFY and GAMUNEX-C, even in the absence of known risk factors. In patients at risk, administer at the minimum dose and infusion rate practicable. Ensure adequate hydration before administration. Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk of hyperviscosity.

Hyperproteinemia, Increased Serum Viscosity, and Hyponatremia. Hyperproteinemia, increased serum viscosity, and hyponatremia may occur in patients receiving IVIG treatment, including GAMUNEX-C.

Aseptic meningitis syndrome (AMS). AMS may occur with human immune globulin treatment, including XEMBIFY and GAMUNEX-C. Conduct a thorough neurological exam on patients exhibiting signs and symptoms of AMS to rule out other causes of meningitis. Discontinuation of treatment has resulted in remission within several days without sequelae.

Renal dysfunction/failure. Acute renal dysfunction/failure, acute tubular necrosis, proximal tubular nephropathy, osmotic nephrosis, and death may occur with use of human immune globulin products, especially those containing sucrose. XEMBIFY and GAMUNEX-C do not contain sucrose. Ensure patients are not volume-depleted prior to starting infusion. In patients at risk due to preexisting renal insufficiency or predisposition to acute renal failure, assess renal function (including blood urea nitrogen (BUN), serum creatinine, and urine output) prior to the initial infusion and again at appropriate intervals thereafter. If renal function deteriorates, consider discontinuation.

Hemolysis. XEMBIFY and GAMUNEX-C may contain blood group antibodies that may cause a positive direct antiglobulin reaction and hemolysis. Monitor patients for clinical signs and symptoms of hemolysis. If signs and symptoms are present after infusion, perform confirmatory lab testing.

Transfusion-related acute lung injury (TRALI). Noncardiogenic pulmonary edema may occur in patients following treatment with immune globulin products, including XEMBIFY and GAMUNEX-C. Monitor patients for pulmonary adverse reactions. If TRALI is suspected, perform appropriate tests for the presence of antineutrophil and anti-HLA antibodies in both the product and patient serum. TRALI may be managed using oxygen therapy with adequate ventilatory support.

Transmissible infectious agents. Because XEMBIFY and GAMUNEX-C are made from human blood, they may carry a risk of transmitting infectious agents, eg, viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

Interference with lab tests. Passively transferred antibodies in the patient’s blood may yield positive serological testing results, with the potential for misleading interpretation.

Adverse Reactions
The most common adverse reactions in ≥ 5% of subjects in clinical trials were:


PIDD, subcutaneous: local adverse reactions, including infusion-site erythema (redness), infusion-site pain, infusion-site swelling (puffiness), infusion-site bruising, infusion-site nodule, infusion-site pruritus (itching), infusion-site induration (firmness), infusion-site scab, infusion-site edema, and systemic reactions including cough and diarrhea.


PIDD, subcutaneous: local infusion-site reactions, fatigue, headache, upper respiratory tract infection, arthralgia, diarrhea, nausea, sinusitis, bronchitis, depression, allergic dermatitis, migraine, myalgia, viral infection, and pyrexia.

PIDD, intravenous: cough, rhinitis, pharyngitis, headache, asthma, nausea, fever, diarrhea, and sinusitis.

The most serious adverse reaction in clinical studies with GAMUNEX-C in PIDD was an exacerbation of autoimmune pure red cell aplasia in 1 subject.

Drug Interactions
Passive transfer of antibodies may transiently interfere with the immune responses to live attenuated virus vaccines (eg, measles, mumps, rubella, and varicella).

Please see accompanying full Prescribing Information for XEMBIFY.

Please see accompanying full Prescribing Information for GAMUNEX-C.

Terms to know

IG, immune globulin; CIDP, chronic inflammatory demyelinating polyneuropathy; PIDD, primary immunodeficiency disease; ITP, idiopathic thrombocytopenic purpura; Sub Q, subcutaneous; IV, intravenous; ICE, 10% caprylate-chromatography purified immune globulin intravenous (IGIV-C) CIDP efficacy.